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Usage Information

Phospholipid signaling in innate immune cells
Valerie B. O’Donnell, … , Jamie Rossjohn, Michael J.O. Wakelam
Valerie B. O’Donnell, … , Jamie Rossjohn, Michael J.O. Wakelam
Published November 19, 2019; First published April 23, 2018
Citation Information: J Clin Invest. 2018;128(7):2670-2679. https://doi.org/10.1172/JCI97944.
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Category: Review Series

Phospholipid signaling in innate immune cells

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Abstract

Phospholipids comprise a large body of lipids that define cells and organelles by forming membrane structures. Importantly, their complex metabolism represents a highly controlled cellular signaling network that is essential for mounting an effective innate immune response. Phospholipids in innate cells are subject to dynamic regulation by enzymes, whose activities are highly responsive to activation status. Along with their metabolic products, they regulate multiple aspects of innate immune cell biology, including shape change, aggregation, blood clotting, and degranulation. Phospholipid hydrolysis provides substrates for cell-cell communication, enables regulation of hemostasis, immunity, thrombosis, and vascular inflammation, and is centrally important in cardiovascular disease and associated comorbidities. Phospholipids themselves are also recognized by innate-like T cells, which are considered essential for recognition of infection or cancer, as well as self-antigens. This Review describes the major phospholipid metabolic pathways present in innate immune cells and summarizes the formation and metabolism of phospholipids as well as their emerging roles in cell biology and disease.

Authors

Valerie B. O’Donnell, Jamie Rossjohn, Michael J.O. Wakelam

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Usage data is cumulative from December 2018 through December 2019.

Usage JCI PMC
Text version 2,009 124
PDF 502 144
Figure 429 0
Supplemental data 88 27
Citation downloads 60 0
Totals 3,088 295
Total Views 3,383

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