Usage Information

IL-6 polymorphisms: a useful genetic tool for inflammation research?
Patricia Woo, Steve E. Humphries
Patricia Woo, Steve E. Humphries
Published April 1, 2013
Citation Information: J Clin Invest. 2013;123(4):1413-1414. https://doi.org/10.1172/JCI67221.
View: Text | PDF
Category: Hindsight

IL-6 polymorphisms: a useful genetic tool for inflammation research?

Abstract

In 1998, we described a novel polymorphism in the promoter (G>C, rs1800795) of the IL-6 (IL6) gene. The common allele, G, exhibited higher transcriptional activity in gene reporter assays and was associated with higher serum IL-6 levels in a small cohort of healthy subjects. We explored the ethnic distribution of these alleles and found significant differences among people of mixed European descent, Africans, and Gujarati Asians. Disease association was established in a cohort of 92 children of mixed European descent from the United Kingdom with systemic juvenile idiopathic arthritis (sJIA), with the GG genotype being significantly increased in sJIA cases compared with that in 383 controls, especially in those under 6 years old (P = 0.01). This polymorphism has since been used as a functional variant to explore the role of elevated IL-6 levels in many common disease states, confirming the key causal role of IL-6 in human health and disease.

Authors

Patricia Woo, Steve E. Humphries

×

Usage data is cumulative from December 2018 through December 2019.

Usage JCI PMC
Text version 309 89
PDF 109 101
Figure 125 0
Supplemental data 17 16
Citation downloads 18 0
Totals 578 206
Total Views 784
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement