Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
I. Sadaf Farooqi, … , Alex M. DePaoli, Stephen O’Rahilly
I. Sadaf Farooqi, … , Alex M. DePaoli, Stephen O’Rahilly
Published October 15, 2002
Citation Information: J Clin Invest. 2002;110(8):1093-1103. https://doi.org/10.1172/JCI15693.
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Categories: Article Metabolism

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Abstract

Research Article

Authors

I. Sadaf Farooqi, Giuseppe Matarese, Graham M. Lord, Julia M. Keogh, Elizabeth Lawrence, Chizo Agwu, Veronica Sanna, Susan A. Jebb, Francesco Perna, Silvia Fontana, Robert I. Lechler, Alex M. DePaoli, Stephen O’Rahilly

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Figure 1

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Effects of r-metHuLeptin on weight in three children with congenital lep...
Effects of r-metHuLeptin on weight in three children with congenital leptin deficiency. (a) Weights of child A compared with normal centiles for girls and of child B and child C compared with normal centiles for boys. Arrows indicate the start of r-metHuLeptin therapy. (b) Clinical photographs of child B before (height = 107 cm) and 24 months after r-metHuLeptin therapy (height = 124 cm) (reproduced with the permission of the child’s parents).