[HTML][HTML] NADPH oxidase restrains the matrix metalloproteinase activity of macrophages
SY Kassim, X Fu, WC Liles, SD Shapiro… - Journal of Biological …, 2005 - ASBMB
Matrix metalloproteinases (MMPs) regulate numerous functions in normal and disease
processes; thus, irreversibly blocking their activity is a key step in regulating MMP catalysis.
We previously showed in vitro that oxidizing intermediates generated by phagocytes
inactivate MMPs by modifying specific amino acids. To assess whether this mechanism
operates in vivo, we focused on MMP-12, a macrophage-specific MMP known to mediate
emphysema in mouse models. We found that mice lacking gp91 phox, a phagocyte-specific …
processes; thus, irreversibly blocking their activity is a key step in regulating MMP catalysis.
We previously showed in vitro that oxidizing intermediates generated by phagocytes
inactivate MMPs by modifying specific amino acids. To assess whether this mechanism
operates in vivo, we focused on MMP-12, a macrophage-specific MMP known to mediate
emphysema in mouse models. We found that mice lacking gp91 phox, a phagocyte-specific …