[HTML][HTML] Dedicated myosin light chain kinases with diverse cellular functions
KE Kamm, JT Stull - Journal of Biological Chemistry, 2001 - ASBMB
Cell signaling events that lead to increased [Ca2+] i 1 in smooth and skeletal muscles
activate Ca2+/calmodulin-dependent MLCK. The kinase phosphorylates a specific site on
the N terminus of the RLC of the molecular motor myosin II (1–3). RLC phosphorylation is
sufficient to initiate contraction in smooth muscle, but in striated muscles, RLC
phosphorylation potentiates the force and speed of contractions that are dependent on Ca2+
binding to troponin on actin-containing thin filaments. The only known physiological …
activate Ca2+/calmodulin-dependent MLCK. The kinase phosphorylates a specific site on
the N terminus of the RLC of the molecular motor myosin II (1–3). RLC phosphorylation is
sufficient to initiate contraction in smooth muscle, but in striated muscles, RLC
phosphorylation potentiates the force and speed of contractions that are dependent on Ca2+
binding to troponin on actin-containing thin filaments. The only known physiological …