Regulatory players of DNA damage repair mechanisms: role in cancer chemoresistance
KM Sakthivel, S Hariharan - Biomedicine & Pharmacotherapy, 2017 - Elsevier
KM Sakthivel, S Hariharan
Biomedicine & Pharmacotherapy, 2017•ElsevierDNA damaging agents are most common in chemotherapeutic molecules that act against
cancer. However, cancer cells possess inherent biological features to overcome DNA
damages by activating various distinct repair mechanisms and pathways. Importantly,
various oncogenes, cancer stem cells (CSCs), hypoxic environment, transcription factors
and bystander signaling that are activated in the cancer cells influence DNA repair, thereby
effectively repairing the DNA damage. Repaired cancer cells often become more resistance …
cancer. However, cancer cells possess inherent biological features to overcome DNA
damages by activating various distinct repair mechanisms and pathways. Importantly,
various oncogenes, cancer stem cells (CSCs), hypoxic environment, transcription factors
and bystander signaling that are activated in the cancer cells influence DNA repair, thereby
effectively repairing the DNA damage. Repaired cancer cells often become more resistance …
Abstract
DNA damaging agents are most common in chemotherapeutic molecules that act against cancer. However, cancer cells possess inherent biological features to overcome DNA damages by activating various distinct repair mechanisms and pathways. Importantly, various oncogenes, cancer stem cells (CSCs), hypoxic environment, transcription factors and bystander signaling that are activated in the cancer cells influence DNA repair, thereby effectively repairing the DNA damage. Repaired cancer cells often become more resistance to further therapy and results in disease recurrence. In this review, we summarize how the various signaling pathways in cancer cells regulates DNA repair and induce chemoresistance.
Elsevier