[HTML][HTML] Selective mutations in estrogen receptor α D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms
KA Burns, Y Li, Y Arao, RM Petrovich… - Journal of Biological …, 2011 - ASBMB
The three main mechanisms of ERα action are: 1) nuclear, genomic, direct DNA binding, 2)
nuclear, genomic," tethered"-mediated, protein-protein interactions, and 3) non-nuclear, non-
genomic, rapid action responses. Reports suggest the D-domain or hinge region of ERα
plays an important role in mechanisms 1 and 2 above. Studies demonstrating the
functionality of the ERα hinge region have resected the full D-domain; therefore, site directed
mutations were made to attribute precise sequence functionality to this domain. This study …
nuclear, genomic," tethered"-mediated, protein-protein interactions, and 3) non-nuclear, non-
genomic, rapid action responses. Reports suggest the D-domain or hinge region of ERα
plays an important role in mechanisms 1 and 2 above. Studies demonstrating the
functionality of the ERα hinge region have resected the full D-domain; therefore, site directed
mutations were made to attribute precise sequence functionality to this domain. This study …