Effect of standard vs dose-escalated radiation therapy for patients with intermediate-risk prostate cancer: the NRG oncology RTOG 0126 randomized clinical trial
JM Michalski, J Moughan, J Purdy, W Bosch… - JAMA …, 2018 - jamanetwork.com
Importance Optimizing radiation therapy techniques for localized prostate cancer can affect
patient outcomes. Dose escalation improves biochemical control, but no prior trials were
powered to detect overall survival (OS) differences. Objective To determine whether
radiation dose escalation to 79.2 Gy compared with 70.2 Gy would improve OS and other
outcomes in prostate cancer. Design, Setting, and Participants The NRG Oncology/RTOG
0126 randomized clinical trial randomized 1532 patients from 104 North American Radiation …
patient outcomes. Dose escalation improves biochemical control, but no prior trials were
powered to detect overall survival (OS) differences. Objective To determine whether
radiation dose escalation to 79.2 Gy compared with 70.2 Gy would improve OS and other
outcomes in prostate cancer. Design, Setting, and Participants The NRG Oncology/RTOG
0126 randomized clinical trial randomized 1532 patients from 104 North American Radiation …