[HTML][HTML] Proximity-dependent mapping of the androgen receptor identifies kruppel-like factor 4 as a functional partner
L Velot, F Lessard, FA Berube-Simard, C Tav… - Molecular & Cellular …, 2021 - ASBMB
Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the third cause of
cancer mortality. PCa initiation and growth are driven by the androgen receptor (AR). The
AR is activated by androgens such as testosterone and controls prostatic cell proliferation
and survival. Here, we report an AR signaling network generated using BioID proximity
labeling proteomics in androgen-dependent LAPC4 cells. We identified 31 AR-associated
proteins in nonstimulated cells. Strikingly, the AR signaling network increased to 182 and …
cancer mortality. PCa initiation and growth are driven by the androgen receptor (AR). The
AR is activated by androgens such as testosterone and controls prostatic cell proliferation
and survival. Here, we report an AR signaling network generated using BioID proximity
labeling proteomics in androgen-dependent LAPC4 cells. We identified 31 AR-associated
proteins in nonstimulated cells. Strikingly, the AR signaling network increased to 182 and …