[HTML][HTML] Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis
KJ Lee, YF Lin, HY Chou, H Yajima, KR Fattah… - Journal of Biological …, 2011 - ASBMB
The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) plays an important role
in DNA double-strand break (DSB) repair as the underlying mechanism of the non-
homologous end joining pathway. When DSBs occur, DNA-PKcs is rapidly phosphorylated
at both the Thr-2609 and Ser-2056 residues, and such phosphorylations are critical for DSB
repair. In this study we report that, in addition to responding to DSBs, DNA-PKcs is activated
and phosphorylated in normal cell cycle progression through mitosis. Mitotic induction of …
in DNA double-strand break (DSB) repair as the underlying mechanism of the non-
homologous end joining pathway. When DSBs occur, DNA-PKcs is rapidly phosphorylated
at both the Thr-2609 and Ser-2056 residues, and such phosphorylations are critical for DSB
repair. In this study we report that, in addition to responding to DSBs, DNA-PKcs is activated
and phosphorylated in normal cell cycle progression through mitosis. Mitotic induction of …