Endurance and resistance exercise training induces specific and profound changes in the
skeletal muscle transcriptome. Peroxisome proliferator-activated receptor γ coactivator-1 α
(PGC-1α) coactivators are not only among the genes differentially induced by distinct
training methods, but they also participate in the ensuing signaling cascades that allow
skeletal muscle to adapt to each type of exercise. Although endurance training preferentially
induces PGC-1α1 expression, resistance exercise activates the expression of PGC-1α2,-α3 …