[HTML][HTML] Hyperhomocysteinemia induces vascular calcification by activating the transcription factor RUNX2 via Krüppel-like factor 4 up-regulation in mice
L Zhu, N Zhang, R Yan, W Yang, G Cong, N Yan… - Journal of Biological …, 2019 - ASBMB
One of the main characteristics of atherosclerosis is vascular calcification, which is linked to
adverse cardiovascular events. Increased homocysteine (Hcy), a feature of
hyperhomocysteinemia, is correlated with advanced vascular calcification and phenotypic
switching of vascular smooth muscle cells (VSMCs). Oxidative stress and high phosphate
levels also induce VSMC calcification, suggesting that the Krüppel-like factor 4 (KLF4)
signaling pathway may also contribute to vascular calcification. In this study, we investigated …
adverse cardiovascular events. Increased homocysteine (Hcy), a feature of
hyperhomocysteinemia, is correlated with advanced vascular calcification and phenotypic
switching of vascular smooth muscle cells (VSMCs). Oxidative stress and high phosphate
levels also induce VSMC calcification, suggesting that the Krüppel-like factor 4 (KLF4)
signaling pathway may also contribute to vascular calcification. In this study, we investigated …