Runt-related transcription factor 2 (RUNX2) is a key transcription factor for bone formation
and osteoblast differentiation. Various signaling pathways and mechanisms that regulate the
expression and transcriptional activity of RUNX2 have been thoroughly investigated since
the involvement of RUNX2 was first reported in bone formation. As the regulation of Runx2
expression by extracellular signals has recently been reviewed, this review focuses on the
regulation of post-translational RUNX2 activity. Transcriptional activity of RUNX2 is …