Hematopoietic stem cell transplantation in autoimmune diseases: the Ahmedabad experience

AV Vanikar, PR Modi, RD Patel, KV Kanodia… - Transplantation …, 2007 - Elsevier
INTRODUCTION: Autoimmune disease represents a (AD) breakdown of natural tolerance
against autoreactive antigens leading to a high mortality and morbidity. The reaction is
usually polyclonal; T-and B-cell components of the hematopoietic system are responsible for
disease progression. Allogeneic/autologous hematopoietic stem cell transplantation (HSCT)
are the current modalities for treating drug-resistant AD. PATIENTS AND METHODS: We
present a single-center retrospective evaluation of allogeneic HSCT with nonmyeloablative …