[HTML][HTML] Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells
L Xue, M Salimi, I Panse, JM Mjösberg… - Journal of allergy and …, 2014 - Elsevier
Background Activation of the group 2 innate lymphoid cell (ILC2) population leads to
production of the classical type 2 cytokines, thus promoting type 2 immunity.
Chemoattractant receptor-homologous molecule expressed on TH 2 cells (CRTH2), a
receptor for prostaglandin D 2 (PGD 2), is expressed by human ILC2s. However, the function
of CRTH2 in these cells is unclear. Objectives We sought to determine the role of PGD 2 and
CRTH2 in human ILC2s and compare it with that of the established ILC2 activators IL-25 and …
production of the classical type 2 cytokines, thus promoting type 2 immunity.
Chemoattractant receptor-homologous molecule expressed on TH 2 cells (CRTH2), a
receptor for prostaglandin D 2 (PGD 2), is expressed by human ILC2s. However, the function
of CRTH2 in these cells is unclear. Objectives We sought to determine the role of PGD 2 and
CRTH2 in human ILC2s and compare it with that of the established ILC2 activators IL-25 and …