Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses
E Segura, S Amigorena, C Théry - Blood Cells, Molecules, and Diseases, 2005 - Elsevier
Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic
cells (DCs) secrete exosomes which transfer functional MHC–peptide complexes to other
DCs. Since immature and mature DCs induce different functional T cell responses (ie,
tolerance versus priming), we asked whether DC maturation also influenced the priming
abilities of their exosomes. We show that immature and mature murine DCs secrete
morphologically similar exosomes. Extensive proteomic analysis of the two exosome …
cells (DCs) secrete exosomes which transfer functional MHC–peptide complexes to other
DCs. Since immature and mature DCs induce different functional T cell responses (ie,
tolerance versus priming), we asked whether DC maturation also influenced the priming
abilities of their exosomes. We show that immature and mature murine DCs secrete
morphologically similar exosomes. Extensive proteomic analysis of the two exosome …