Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity [S]
C Bindesbøll, Q Fan, RC Nørgaard, L MacPherson… - Journal of lipid …, 2015 - ASBMB
Liver X receptor (LXR) α and LXRβ play key roles in hepatic de novo lipogenesis through
their regulation of lipogenic genes, including sterol regulatory element-binding protein
(SREBP)-1c and carbohydrate responsive element-binding protein (ChREBP). LXRs
activate lipogenic gene transcription in response to feeding, which is believed to be
mediated by insulin. We have previously shown that LXRs are targets for glucose-
hexosamine-derived O-linked β-N-acetylglucosamine (O-GlcNAc) modification enhancing …
their regulation of lipogenic genes, including sterol regulatory element-binding protein
(SREBP)-1c and carbohydrate responsive element-binding protein (ChREBP). LXRs
activate lipogenic gene transcription in response to feeding, which is believed to be
mediated by insulin. We have previously shown that LXRs are targets for glucose-
hexosamine-derived O-linked β-N-acetylglucosamine (O-GlcNAc) modification enhancing …
