[HTML][HTML] Increased expression of hypoxia-inducible factor 1α in type I and type II endometrial carcinomas

V Pansare, AR Munkarah, V Schimp, MH Arabi… - Modern Pathology, 2007 - Elsevier
Hypoxia-inducible factor 1α (HIF-1α) is a nuclear protein that is upregulated in many tumors
and triggers biologic events intimately associated with aggressive tumor behavior. The aim
of this study was to analyze the expression of HIF-1α, vascular endothelial growth factor
(VEGF), Ki-67 and p53 in type I and type II endometrial adenocarcinoma. In total, 149
patients diagnosed with endometrial adenocarcinoma in our institute from 1995 to 2001
were included in this study, of which 108 were type I and 41 were type II endometrial …