Role of cholangioles in restoration of the liver of the mouse after dietary injury.

JW Wilson, EH Leduc - Journal of Pathology and Bacteriology, 1958 - cabdirect.org
JW Wilson, EH Leduc
Journal of Pathology and Bacteriology, 1958cabdirect.org
After 60 to 80 days on a semi-synthetic diet containing 1 per cent. dl-methionine and
bentonite the livers of young mice showed reduced numbers of enlarged undivided
parenchymal cells, and many thickened proliferating cholangiole cells with cytoplasm
showing intense alkaline phosphatase activity. On return to a normal diet the enlarged
parenchymal cells disappeared and new parenchyma seemed to be formed from the
cholangiole cells.-E. Hobson.
Abstract
After 60 to 80 days on a semi-synthetic diet containing 1 per cent. dl-methionine and bentonite the livers of young mice showed reduced numbers of enlarged undivided parenchymal cells, and many thickened proliferating cholangiole cells with cytoplasm showing intense alkaline phosphatase activity. On return to a normal diet the enlarged parenchymal cells disappeared and new parenchyma seemed to be formed from the cholangiole cells.-E. Hobson.
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