Reduced startle habituation and prepulse inhibition in mice lacking the adenosine A2A receptor
JH Wang, J Short, C Ledent, AJ Lawrence… - Behavioural brain …, 2003 - Elsevier
JH Wang, J Short, C Ledent, AJ Lawrence, M van den Buuse
Behavioural brain research, 2003•ElsevierAdenosine and dopamine receptors interact in the CNS to modulate behaviour, including
sensorimotor gating. Prepulse inhibition (PPI) has been suggested to be an operational
measure of sensorimotor gating. PPI and startle habituation are disrupted in patients with
schizophrenia. In experimental animals, both parameters are modulated by dopaminergic
and adenosine receptor agonists and antagonists. In the present study, we measured PPI
and startle habituation in mice that lack functional adenosine A2A receptors. Startle …
sensorimotor gating. Prepulse inhibition (PPI) has been suggested to be an operational
measure of sensorimotor gating. PPI and startle habituation are disrupted in patients with
schizophrenia. In experimental animals, both parameters are modulated by dopaminergic
and adenosine receptor agonists and antagonists. In the present study, we measured PPI
and startle habituation in mice that lack functional adenosine A2A receptors. Startle …
Adenosine and dopamine receptors interact in the CNS to modulate behaviour, including sensorimotor gating. Prepulse inhibition (PPI) has been suggested to be an operational measure of sensorimotor gating. PPI and startle habituation are disrupted in patients with schizophrenia. In experimental animals, both parameters are modulated by dopaminergic and adenosine receptor agonists and antagonists. In the present study, we measured PPI and startle habituation in mice that lack functional adenosine A2A receptors. Startle amplitudes, startle habituation and PPI were significantly reduced in mice homozygous null for the adenosine A2A receptor (A2A−/−). In addition, differential effects of amphetamine and MK-801 on startle amplitude, startle habituation and PPI were observed between A2A−/− and wildtype controls. These data support the involvement of adenosine A2A receptors in regulation of PPI and startle habituation.
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