Intraflagellar transport proteins are essential for cilia formation and for planar cell polarity
Y Cao, A Park, Z Sun - Journal of the American Society of …, 2010 - journals.lww.com
The highly conserved intraflagellar transport (IFT) proteins are essential for cilia formation in
multiple organisms, but surprisingly, cilia form in multiple zebrafish ift mutants. Here, we
detected maternal deposition of ift gene products in zebrafish and found that ciliary
assembly occurs only during early developmental stages, supporting the idea that maternal
contribution of ift gene products masks the function of IFT proteins during initial
development. In addition, the basal bodies in multiciliated cells of the pronephric duct in ift …
multiple organisms, but surprisingly, cilia form in multiple zebrafish ift mutants. Here, we
detected maternal deposition of ift gene products in zebrafish and found that ciliary
assembly occurs only during early developmental stages, supporting the idea that maternal
contribution of ift gene products masks the function of IFT proteins during initial
development. In addition, the basal bodies in multiciliated cells of the pronephric duct in ift …
