[HTML][HTML] IKKα at the crossroads of inflammation and metastasis
NI Affara, LM Coussens - Cell, 2007 - cell.com
Cell, 2007•cell.com
The development of solid tumors is regulated by dynamic interactions between evolving
neoplastic cells and their microenvironment. Luo et al.(2007) recently demonstrated that
tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization
of IKKα in prostatic epithelial tumor cells. This leads to repression of maspin, a critical
suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a
metastatic fate.
neoplastic cells and their microenvironment. Luo et al.(2007) recently demonstrated that
tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization
of IKKα in prostatic epithelial tumor cells. This leads to repression of maspin, a critical
suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a
metastatic fate.
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKα in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.
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