Efficient Removal of Immunoglobulin Free Light Chains by Hemodialysis for Multiple Myeloma: In Vitro: and: In Vivo: Studies
CA Hutchison, P Cockwell, S Reid… - Journal of the …, 2007 - journals.lww.com
Of patients with newly diagnosed multiple myeloma, approximately 10% have dialysis-
dependent acute renal failure, with cast nephropathy, caused by monoclonal free light
chains (FLC). Of these, 80 to 90% require long-term renal replacement therapy. Early
treatment by plasma exchange reduces serum FLC concentrations, but randomized,
controlled trials have shown no evidence of renal recovery. This outcome can be explained
by the low efficiency of the procedure. A model of FLC production, distribution, and …
dependent acute renal failure, with cast nephropathy, caused by monoclonal free light
chains (FLC). Of these, 80 to 90% require long-term renal replacement therapy. Early
treatment by plasma exchange reduces serum FLC concentrations, but randomized,
controlled trials have shown no evidence of renal recovery. This outcome can be explained
by the low efficiency of the procedure. A model of FLC production, distribution, and …