Contact dermatitis in the United States: epidemiology, economic impact, and workplace prevention
MW Cashman, PA Reutemann, A Ehrlich - Dermatologic clinics, 2012 - derm.theclinics.com
Irritant contact dermatitis (ICD) is caused by an external agent acting merely as a chemical
or physical irritant, thus eliciting a nonallergic inflammatory host response. The potential to
cause irritation and intensity of the reaction depends on certain features of the agent
including its concentration, pH, vehicle, and length of exposure. ICD only occurs above a
threshold level, which varies from person to person depending on the penetrability and
thickness of the stratum corneum. 2 Very strong irritants elicit an acute reaction after first …
or physical irritant, thus eliciting a nonallergic inflammatory host response. The potential to
cause irritation and intensity of the reaction depends on certain features of the agent
including its concentration, pH, vehicle, and length of exposure. ICD only occurs above a
threshold level, which varies from person to person depending on the penetrability and
thickness of the stratum corneum. 2 Very strong irritants elicit an acute reaction after first …