[HTML][HTML] Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5
The extracellular-regulated kinase (ERK) 4 (MAPK4) and ERK3 (MAPK6) are structurally
related atypical MAPKs displaying major differences only in the C-terminal extension. ERK3
is known as an unstable mostly cytoplasmic protein that binds, translocates, and activates
the MAPK-activated protein kinase (MK) 5. Here we have investigated the stability and
expression of ERK4 and have analyzed its ability to bind, translocate, and activate MK5. We
show that, in contrast to ERK3, ERK4 is a stable protein that binds to endogenous MK5 …
related atypical MAPKs displaying major differences only in the C-terminal extension. ERK3
is known as an unstable mostly cytoplasmic protein that binds, translocates, and activates
the MAPK-activated protein kinase (MK) 5. Here we have investigated the stability and
expression of ERK4 and have analyzed its ability to bind, translocate, and activate MK5. We
show that, in contrast to ERK3, ERK4 is a stable protein that binds to endogenous MK5 …