[HTML][HTML] The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade
GLJ Fuller, JAE Williams, MG Tomlinson… - Journal of Biological …, 2007 - ASBMB
The two lectin receptors, CLEC-2 and Dectin-1, have been shown to signal through a Syk-
dependent pathway, despite the presence of only a single YXXL in their cytosolic tails. In this
study, we show that stimulation of CLEC-2 in platelets and in two mutant cell lines is
dependent on the YXXL motif and on proteins that participate in signaling by
immunoreceptor tyrosine-based activation motif receptors, including Src, Syk, and Tec family
kinases, and on phospholipase Cγ. Strikingly, mutation of either Src homology (SH) 2 …
dependent pathway, despite the presence of only a single YXXL in their cytosolic tails. In this
study, we show that stimulation of CLEC-2 in platelets and in two mutant cell lines is
dependent on the YXXL motif and on proteins that participate in signaling by
immunoreceptor tyrosine-based activation motif receptors, including Src, Syk, and Tec family
kinases, and on phospholipase Cγ. Strikingly, mutation of either Src homology (SH) 2 …