[HTML][HTML] Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
T Plo, T Kok, VW Bloks, MJ Smit, R Havinga… - Journal of Biological …, 2002 - ASBMB
The ATP-binding cassette transporter ABCA1 is essential for high density lipoprotein (HDL)
formation and considered rate-controlling for reverse cholesterol transport. Expression of the
Abca1 gene is under control of the liver X receptor (LXR). We have evaluated effects of LXR
activation by the synthetic agonist T0901317 on hepatic and intestinal cholesterol
metabolism in C57BL/6J and DBA/1 wild-type mice and in ABCA1-deficient DBA/1 mice. In
wild-type mice, T0901317 increased expression of Abca1 in liver and intestine, which was …
formation and considered rate-controlling for reverse cholesterol transport. Expression of the
Abca1 gene is under control of the liver X receptor (LXR). We have evaluated effects of LXR
activation by the synthetic agonist T0901317 on hepatic and intestinal cholesterol
metabolism in C57BL/6J and DBA/1 wild-type mice and in ABCA1-deficient DBA/1 mice. In
wild-type mice, T0901317 increased expression of Abca1 in liver and intestine, which was …