Lipoprotein lipase (LPL) is a key enzyme for lipoprotein metabolism and is responsible for
hydrolysis of triglycerides in circulating lipoproteins, releasing free fatty acids to peripheral
tissues. In liver, LPL is also believed to promote uptake of high density lipoprotein (HDL)-
cholesterol and thereby facilitate reverse cholesterol transport. In this study we show that the
Lpl gene is a direct target of the oxysterol liver X receptor, LXRα. Mice fed diets containing
high cholesterol or an LXR-selective agonist exhibited a significant increase in LPL …