[HTML][HTML] Expression of SUMO-2/3 induced senescence through p53-and pRB-mediated pathways
T Li, R Santockyte, RF Shen, E Tekle, G Wang… - Journal of Biological …, 2006 - ASBMB
Three highly homologous small ubiquitin-related modifier (SUMO) proteins have been
identified in mammals. Modifications of proteins by SUMO-1 have been shown to regulate
transcription, nucleocytoplasmic transport, protein stability, and protein-protein interactions.
Relative to SUMO-1, little is known about the functions of SUMO-2 or SUMO-3 (referred to as
SUMO-2/3). Here, stable cell lines overexpressing processed forms of SUMO-2/3 (SUMO-
2/3GG) as well as their non-conjugatable derivatives, SUMO-2/3ΔGG, were established …
identified in mammals. Modifications of proteins by SUMO-1 have been shown to regulate
transcription, nucleocytoplasmic transport, protein stability, and protein-protein interactions.
Relative to SUMO-1, little is known about the functions of SUMO-2 or SUMO-3 (referred to as
SUMO-2/3). Here, stable cell lines overexpressing processed forms of SUMO-2/3 (SUMO-
2/3GG) as well as their non-conjugatable derivatives, SUMO-2/3ΔGG, were established …