Gains in bone mineral density with resolution of vitamin D intoxication
JS Adams, G Lee - Annals of internal medicine, 1997 - acpjournals.org
JS Adams, G Lee
Annals of internal medicine, 1997•acpjournals.orgBackground: Vitamin D intoxication is associated with the mobilization of skeletal calcium.
Objective: To ascertain how the resolution of vitamin D intoxication affects bone density.
Design: Case series. Setting: Referral service for metabolic bone disease in a tertiary care
teaching hospital. Patients: Four patients with osteoporosis who were each using several
nonprescription dietary supplements and were found to have fasting hypercalciuria.
Intervention: Discontinuation of use of dietary supplements. Measurements: Serial …
Objective: To ascertain how the resolution of vitamin D intoxication affects bone density.
Design: Case series. Setting: Referral service for metabolic bone disease in a tertiary care
teaching hospital. Patients: Four patients with osteoporosis who were each using several
nonprescription dietary supplements and were found to have fasting hypercalciuria.
Intervention: Discontinuation of use of dietary supplements. Measurements: Serial …
Background
Vitamin D intoxication is associated with the mobilization of skeletal calcium.
Objective
To ascertain how the resolution of vitamin D intoxication affects bone density.
Design
Case series.
Setting
Referral service for metabolic bone disease in a tertiary care teaching hospital.
Patients
Four patients with osteoporosis who were each using several nonprescription dietary supplements and were found to have fasting hypercalciuria.
Intervention
Discontinuation of use of dietary supplements.
Measurements
Serial measurement of serum levels of 25-hydroxyvitamin D, ratio of fasting urinary calcium to creatinine, and bone mineral density for 3 years.
Results
Discontinuation of use of dietary supplements resulted in the normalization of serum levels of 25-hydroxyvitamin D, the normalization of the ratio of urinary calcium to creatinine, and a mean annual increase in bone mineral density (±SD) of 1.9% ± 0.6%.
Conclusions
Occult vitamin D intoxication was detected in patients who were using dietary supplements that contained an unadvertised high level of vitamin D. Resolution of vitamin D intoxication was associated with a rebound in bone mineral density.
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