[HTML][HTML] Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
The sphingolipid ceramide negatively regulates insulin action by inhibiting Akt/protein
kinase B (PKB), a serine/threonine kinase that is a central regulator of glucose uptake and
anabolic metabolism. Despite considerable attention, the molecular mechanism accounting
for this action of ceramide has remained both elusive and controversial. Herein we utilized
deletion constructs encoding two different functional domains of Akt/PKB to identify which
region of the enzyme conferred responsiveness to ceramide. Surprisingly the findings …
kinase B (PKB), a serine/threonine kinase that is a central regulator of glucose uptake and
anabolic metabolism. Despite considerable attention, the molecular mechanism accounting
for this action of ceramide has remained both elusive and controversial. Herein we utilized
deletion constructs encoding two different functional domains of Akt/PKB to identify which
region of the enzyme conferred responsiveness to ceramide. Surprisingly the findings …