[HTML][HTML] Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor α
The insulin-responsive glucose transporter GLUT4 plays a crucial role in insulin-mediated
facilitated glucose uptake into adipose tissue and muscle, and impaired expression of
GLUT4 has been linked to obesity and diabetes. In this study, we demonstrate that liver X
receptors (LXRs) regulate the expression of GLUT4 through direct interaction with a
conserved LXR response element in the GLUT4 promoter. The expression of GLUT4 in WAT
is induced by a potent LXR agonist in wild type, LXRα-/-, and LXRβ-/-mice but not in LXRα …
facilitated glucose uptake into adipose tissue and muscle, and impaired expression of
GLUT4 has been linked to obesity and diabetes. In this study, we demonstrate that liver X
receptors (LXRs) regulate the expression of GLUT4 through direct interaction with a
conserved LXR response element in the GLUT4 promoter. The expression of GLUT4 in WAT
is induced by a potent LXR agonist in wild type, LXRα-/-, and LXRβ-/-mice but not in LXRα …