[HTML][HTML] AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its …
S Vernia, MC Solaz-Fuster, JV Gimeno-Alcanñiz… - Journal of biological …, 2009 - ASBMB
R5/PTG is one of the glycogen targeting subunits of type 1 protein phosphatase, a master
regulator of glycogen synthesis. R5/PTG recruits the phosphatase to the places where
glycogen synthesis occurs, allowing the activation of glycogen synthase and the inactivation
of glycogen phosphorylase, thus increasing glycogen synthesis and decreasing its
degradation. In this report, we show that the activity of R5/PTG is regulated by AMP-activated
protein kinase (AMPK). We demonstrate that AMPK interacts physically with R5/PTG and …
regulator of glycogen synthesis. R5/PTG recruits the phosphatase to the places where
glycogen synthesis occurs, allowing the activation of glycogen synthase and the inactivation
of glycogen phosphorylase, thus increasing glycogen synthesis and decreasing its
degradation. In this report, we show that the activity of R5/PTG is regulated by AMP-activated
protein kinase (AMPK). We demonstrate that AMPK interacts physically with R5/PTG and …