Pancreatic Islet Expression of the Homeobox Factor STF-1 Relies on an E-box Motif That Binds USF (∗)
S Sharma, J Leonard, S Lee, HD Chapman… - Journal of Biological …, 1996 - ASBMB
The commitment of cells to specific lineages during development is determined in large part
by the relative expression of various homeodomain (HOX) selector proteins, which mediate
the activation of distinct genetic programs. But the mechanisms by which individual HOX
genes are themselves targeted for expression in different cell types remain largely
uncharacterized. Here, we demonstrate that STF-1, a homeodomain protein that functions in
pancreatic morphogenesis and in glucose homeostasis is encoded by an" orphan" …
by the relative expression of various homeodomain (HOX) selector proteins, which mediate
the activation of distinct genetic programs. But the mechanisms by which individual HOX
genes are themselves targeted for expression in different cell types remain largely
uncharacterized. Here, we demonstrate that STF-1, a homeodomain protein that functions in
pancreatic morphogenesis and in glucose homeostasis is encoded by an" orphan" …
