[HTML][HTML] T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis
A Blauvelt - Journal of Investigative Dermatology, 2008 - Elsevier
Journal of Investigative Dermatology, 2008•Elsevier
T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and
Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune
inflammatory diseases (Figure 1)(Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates
survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for
these diseases.
Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune
inflammatory diseases (Figure 1)(Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates
survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for
these diseases.
T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.
Elsevier