[HTML][HTML] Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine …
C Taghibiglou, F Rashid-Kolvear… - Journal of Biological …, 2002 - ASBMB
A fructose-fed hamster model of insulin resistance was previously documented to exhibit
marked hepatic very low density lipoprotein (VLDL) overproduction. Here, we investigated
whether VLDL overproduction was associated with down-regulation of hepatic insulin
signaling and insulin resistance. Hepatocytes isolated from fructose-fed hamsters exhibited
significantly reduced tyrosine phosphorylation of the insulin receptor and insulin receptor
substrates 1 and 2. Phosphatidylinositol 3-kinase activity as well as insulin-stimulated Akt …
marked hepatic very low density lipoprotein (VLDL) overproduction. Here, we investigated
whether VLDL overproduction was associated with down-regulation of hepatic insulin
signaling and insulin resistance. Hepatocytes isolated from fructose-fed hamsters exhibited
significantly reduced tyrosine phosphorylation of the insulin receptor and insulin receptor
substrates 1 and 2. Phosphatidylinositol 3-kinase activity as well as insulin-stimulated Akt …
