Preclinical and clinical development of novel agents that target the protein kinase C family
M Serova, A Ghoul, KA Benhadji, E Cvitkovic… - Seminars in …, 2006 - Elsevier
Protein kinase C (PKC) family comprises more than 12 serine-/threonine-specific
isoenzymes. PKC isoenzymes play a complex role in the transduction of signal from tyrosine
kinase receptor modulating proliferation, cell cycle, apoptosis, invasion, differentiation, and
senescence in both cancer cells and endothelial cells. Thereby, inhibition and/or activation
of specific PKCs is thought to control tumor growth by interacting directly with cancer cells
and indirectly by blocking tumor angiogenesis. Furthermore, PKCs are known to modulate …
isoenzymes. PKC isoenzymes play a complex role in the transduction of signal from tyrosine
kinase receptor modulating proliferation, cell cycle, apoptosis, invasion, differentiation, and
senescence in both cancer cells and endothelial cells. Thereby, inhibition and/or activation
of specific PKCs is thought to control tumor growth by interacting directly with cancer cells
and indirectly by blocking tumor angiogenesis. Furthermore, PKCs are known to modulate …
