Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins: activation of StARD4 by sterol regulatory element-binding protein-2 and StARD5 by …
RE Soccio, RM Adams, KN Maxwell… - Journal of Biological …, 2005 - ASBMB
The StarD4 and StarD5 proteins share∼ 30% identity, and each is a steroidogenic acute
regulatory protein (StAR)-related lipid transfer (START) domain. We previously showed
StarD4 expression is sterol-repressed, consistent with regulation by sterol regulatory
element-binding proteins (SREBPs), whereas StarD5 is not sterol-regulated. Here we further
address the regulation and function of StarD4 and StarD5. Unlike StAR, the START family
prototype, StarD4 and StarD5 were not induced by steroidogenic stimuli in Leydig cells …
regulatory protein (StAR)-related lipid transfer (START) domain. We previously showed
StarD4 expression is sterol-repressed, consistent with regulation by sterol regulatory
element-binding proteins (SREBPs), whereas StarD5 is not sterol-regulated. Here we further
address the regulation and function of StarD4 and StarD5. Unlike StAR, the START family
prototype, StarD4 and StarD5 were not induced by steroidogenic stimuli in Leydig cells …
