The genetic manipulation of mice has provided an invaluable tool for studying the molecular
mechanism (s) involved in atherosclerotic lesion development and maturation. The use of
these new animal models has demonstrated that leukocyte-endothelium adhesion receptors
play a significant part in promoting monocyte recruitment and consequently lesion growth.
The next phase of investigation should test whether the inhibition of these adhesion
receptors can reproduce the powerful anti-atherosclerotic effects seen in the adhesion …