[HTML][HTML] Regulating the balance between peroxisome proliferator-activated receptor γ and β-catenin signaling during adipogenesis: a glycogen synthase kinase 3β …
J Liu, SR Farmer - Journal of Biological Chemistry, 2004 - ASBMB
The differentiation of preadipocytes into adipocytes requires the suppression of canonical
Wnt signaling, which appears to involve a peroxisome proliferator-activated receptor γ
(PPARγ)-associated targeting of β-catenin to the proteasome. In fact, sustained activation of
β-catenin by expression of Wnt1 or Wnt 10b in preadipocytes blocks adipogenesis by
inhibiting PPARγ-associated gene expression. In this report, we investigated the
mechanisms regulating the balance between β-catenin and PPARγ signaling that …
Wnt signaling, which appears to involve a peroxisome proliferator-activated receptor γ
(PPARγ)-associated targeting of β-catenin to the proteasome. In fact, sustained activation of
β-catenin by expression of Wnt1 or Wnt 10b in preadipocytes blocks adipogenesis by
inhibiting PPARγ-associated gene expression. In this report, we investigated the
mechanisms regulating the balance between β-catenin and PPARγ signaling that …
