[HTML][HTML] Regulation of calcium/calmodulin-dependent protein Kinase II docking toN-Methyl-d-aspartate receptors by calcium/calmodulin and α-actinin
AS Leonard, KU Bayer, MA Merrill, IA Lim… - Journal of Biological …, 2002 - ASBMB
Ca 2+ influx through theN-methyl-d-aspartate (NMDA)-type glutamate receptor leads to
activation and postsynaptic accumulation of Ca 2+/calmodulin-dependent protein kinase II
(CaMKII) and ultimately to long term potentiation, which is thought to be the physiological
correlate of learning and memory. The NMDA receptor also serves as a CaMKII docking site
in dendritic spines with high affinity binding sites located on its NR1 and NR2B subunits. We
demonstrate that high affinity binding of CaMKII to NR1 requires autophosphorylation of Thr …
activation and postsynaptic accumulation of Ca 2+/calmodulin-dependent protein kinase II
(CaMKII) and ultimately to long term potentiation, which is thought to be the physiological
correlate of learning and memory. The NMDA receptor also serves as a CaMKII docking site
in dendritic spines with high affinity binding sites located on its NR1 and NR2B subunits. We
demonstrate that high affinity binding of CaMKII to NR1 requires autophosphorylation of Thr …
