Post-training administration of anandamide (1.5, 3, 6 mg/kg) dose-dependently impaired
retention of an inhibitory avoidance response in DBA/2 mice, while improving it in C57BL/6
mice. The effects on retention performance induced by the drug appear to be due to an effect
on memory consolidation. They were observed when drug was given at short, but not long,
periods of time after training, ie when the memory trace was susceptible to modulation.
These effects of anandamide parallel those of opioid agonists, as previously reported …