[HTML][HTML] Nicotine inactivation of the proapoptotic function of Bax through phosphorylation
M Xin, X Deng - Journal of Biological Chemistry, 2005 - ASBMB
Nicotine-induced cell survival is associated with chemoresistance of human lung cancer
cells, but our understanding of the intracellular mechanism (s) is fragmentary. Bax is a major
proapoptotic member of the Bcl2 family and a molecule required for apoptotic cell death.
Growth factor (ie granulocyte-macrophage colony-stimulating factor)-induced
phosphorylation of Bax has been reported to negatively regulate its proapoptotic function.
Because Bax is ubiquitously expressed in both small cell lung cancer and non-small cell …
cells, but our understanding of the intracellular mechanism (s) is fragmentary. Bax is a major
proapoptotic member of the Bcl2 family and a molecule required for apoptotic cell death.
Growth factor (ie granulocyte-macrophage colony-stimulating factor)-induced
phosphorylation of Bax has been reported to negatively regulate its proapoptotic function.
Because Bax is ubiquitously expressed in both small cell lung cancer and non-small cell …