DNA adduct formation from tobacco-specific N-nitrosamines
SS Hecht - … Research/Fundamental and Molecular Mechanisms of …, 1999 - Elsevier
Tobacco-specific N-nitrosamines are a group of carcinogens derived from the tobacco
alkaloids. They are likely causative factors for cancers of the lung, esophagus, pancreas,
and oral cavity in people who use tobacco products. The most carcinogenic tobacco-specific
nitrosamines in laboratory animals are 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N′-nitrosonornicotine
(NNN). DNA adduct formation from NNK and NNN has been studied extensively and is …
alkaloids. They are likely causative factors for cancers of the lung, esophagus, pancreas,
and oral cavity in people who use tobacco products. The most carcinogenic tobacco-specific
nitrosamines in laboratory animals are 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N′-nitrosonornicotine
(NNN). DNA adduct formation from NNK and NNN has been studied extensively and is …
