Crystal-neutrophil interactions lead to interleukin-1 synthesis
CJ Roberge, J Grassi, R De Medicis, Y Frobert… - Agents and Actions, 1991 - Springer
CJ Roberge, J Grassi, R De Medicis, Y Frobert, A Lussier, PH Naccache, PE Poubelle
Agents and Actions, 1991•SpringerNormal human blood neutrophils were studied for their capacity to synthesize and release
interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and
calcium pyrophosphate dihydrate crystals (CPPD). MSU crystals were more potent inducers
of IL-1 generation than CPPD or unopsonized zymosan. Microcrystal-stimulated neutrophils
characteristically secreted most of the newly synthesized IL-1. Colchicine partly inhibited the
secretion of IL-1 by neutrophils during phagocytosis of solid particles. However, colchicine …
interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and
calcium pyrophosphate dihydrate crystals (CPPD). MSU crystals were more potent inducers
of IL-1 generation than CPPD or unopsonized zymosan. Microcrystal-stimulated neutrophils
characteristically secreted most of the newly synthesized IL-1. Colchicine partly inhibited the
secretion of IL-1 by neutrophils during phagocytosis of solid particles. However, colchicine …
Abstract
Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD). MSU crystals were more potent inducers of IL-1 generation than CPPD or unopsonized zymosan. Microcrystal-stimulated neutrophils characteristically secreted most of the newly synthesized IL-1. Colchicine partly inhibited the secretion of IL-1 by neutrophils during phagocytosis of solid particles. However, colchicine selectively inhibited IL-1 synthesis induced by microcrystals. These results suggest that neutrophil-derived IL-1 may contribute to the pathogenesis of crystal-induced arthritis.
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