Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of PAF-acether
M Sánchez-Crespo, S Fernández-Gallardo… - …, 1985 - Elsevier
The effect of BN 52021, a selective antagonist of paf-acether (Braquet GB patent 8, 418, 424
July 19, 1984), was studied in normotensive rats challenged with different doses of paf-
acether. Sudden death was observed in animals receiving an iv dose of 10 μg/kg of paf-
acether and this was prevented by prior treatment with BN 52021 (5 mg/kg, iv). Animals
receiving 2.5 μg/kg of paf-acether had a fall of mean arterial pressure of 92.5±4.7 mmHg
which recovered to the prechallenge level 20.5±0.2 min thereafter. Previous treatment with …
July 19, 1984), was studied in normotensive rats challenged with different doses of paf-
acether. Sudden death was observed in animals receiving an iv dose of 10 μg/kg of paf-
acether and this was prevented by prior treatment with BN 52021 (5 mg/kg, iv). Animals
receiving 2.5 μg/kg of paf-acether had a fall of mean arterial pressure of 92.5±4.7 mmHg
which recovered to the prechallenge level 20.5±0.2 min thereafter. Previous treatment with …
