[HTML][HTML] Resistance to Endotoxic Shock in Endothelial Nitric-oxide Synthase (eNOS) Knock-out Mice: A PRO-INFLAMMATORY ROLE FOR eNOS-DERIVED NO IN …
The expression of inducible nitric-oxide synthase (iNOS) and subsequent" high-output" nitric
oxide (NO) production underlies the systemic hypotension, inadequate tissue perfusion, and
organ failure associated with septic shock. Therefore, modulators of iNOS expression and
activity, both endogenous and exogenous, are important in determining the magnitude and
time course of this condition. We have shown previously that NO from the constitutive
endothelial NOS (eNOS) is necessary to obtain maximal iNOS expression and activity …
oxide (NO) production underlies the systemic hypotension, inadequate tissue perfusion, and
organ failure associated with septic shock. Therefore, modulators of iNOS expression and
activity, both endogenous and exogenous, are important in determining the magnitude and
time course of this condition. We have shown previously that NO from the constitutive
endothelial NOS (eNOS) is necessary to obtain maximal iNOS expression and activity …