[HTML][HTML] Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells
FJ Warner, RA Lew, AI Smith, DW Lambert… - Journal of Biological …, 2005 - ASBMB
Angiotensin-converting enzyme-2 (ACE2) is a homologue of angiotensin-I converting
enzyme (ACE), the central enzyme of the renin-angiotensin system (RAS). ACE2 is
abundant in human kidney and heart and has been implicated in renal and cardiac function
through its ability to hydrolyze Angiotensin II. Although ACE2 and ACE are both type I
integral membrane proteins and share 61% protein sequence similarity, they display distinct
modes of enzyme action and tissue distribution. This study characterized ACE2 at the …
enzyme (ACE), the central enzyme of the renin-angiotensin system (RAS). ACE2 is
abundant in human kidney and heart and has been implicated in renal and cardiac function
through its ability to hydrolyze Angiotensin II. Although ACE2 and ACE are both type I
integral membrane proteins and share 61% protein sequence similarity, they display distinct
modes of enzyme action and tissue distribution. This study characterized ACE2 at the …
