The eag potassium channel binds and locally activates calcium/calmodulin-dependent protein kinase II
Ca 2+/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the
regulation of neuronal excitability in many systems. Recent studies suggest that local
regulation of membrane potential can have important computational consequences for
neuronal function. In Drosophila, CaMKII regulates the eag potassium channel, but if and
how this regulation was spatially restricted was unknown. Using coimmunoprecipitation from
head extracts and in vitro binding assays, we show that CaMKII and Eag form a stable …
regulation of neuronal excitability in many systems. Recent studies suggest that local
regulation of membrane potential can have important computational consequences for
neuronal function. In Drosophila, CaMKII regulates the eag potassium channel, but if and
how this regulation was spatially restricted was unknown. Using coimmunoprecipitation from
head extracts and in vitro binding assays, we show that CaMKII and Eag form a stable …