[HTML][HTML] Participation of macrophages in atherosclerotic lesion morphology in LDLr−/− mice
NK Schiller, AS Black, GP Bradshaw, DJ Bonnet… - Journal of lipid …, 2004 - ASBMB
Lyst beige (beige) mice crossed with LDL receptor-deficient (LDLr−/−) mice had a distinct
atherosclerotic lesion morphology that was not observed in LDLr−/− mice. This morphology
is often associated with a stable plaque phenotype. We hypothesized that macrophage
expression of the beige mutation accounted for this distinct morphology. Cultured bone
marrow-derived macrophages from LDLr−/− and beige, LDLr−/− mice were compared for
their ability to accumulate cholesterol, efflux cholesterol, migrate in response to chemotactic …
atherosclerotic lesion morphology that was not observed in LDLr−/− mice. This morphology
is often associated with a stable plaque phenotype. We hypothesized that macrophage
expression of the beige mutation accounted for this distinct morphology. Cultured bone
marrow-derived macrophages from LDLr−/− and beige, LDLr−/− mice were compared for
their ability to accumulate cholesterol, efflux cholesterol, migrate in response to chemotactic …
